A 12-week neuromuscular training program does not reduce mediolateral knee load distribution (key predictor of osteoarthritis structural disease progression) compared with no exercise in patients aged 30 to 50 years with no-to-mild pain after medial arthroscopic partial meniscectomy

A multimodal non-surgical management (exercise, education, use of insoles, dietary advice, pain medication) is more effective than usual care alone (information and advice) for improving knee pain and function as well as quality of life at one-year follow-up in patients with moderate-to-severe knee osteoarthritis

Knee arthroscopy (lavage plus debridement) together with physical (exercise plus education) and medical therapy (pain medication) does not provide additional benefits than physical and medical therapy alone in improving knee pain and function at two-years follow-up in patients with moderate-to-severe knee osteoarthritis

Neither needle nor laser acupuncture provides additional benefits over sham laser acupuncture in reducing knee pain and improving function at one-year follow-up in patients with chronic knee pain older than 50 years

Intra-articular injections of hylan does not result in higher pain relief compared with injections of two different hyaluronic acid preparations at six-months follow-up in patients with symptomatic knee osteoarthritis